Xenapril. Catapres (clonidine) is a medication that was initially approved to treat people with high blood pressure. Xenapril

 
Catapres (clonidine) is a medication that was initially approved to treat people with high blood pressureXenapril  We studied the effect of an angiotensin-converting--enzyme inhibitor, enalapril, on total mortality and mortality from cardiovascular causes, the development of heart failure, and

5 and 4. For further information call emc accessibility on 0800 198 5000 . a change in the way that foods taste. AMD. Who can and cannot take it. 15 release, The Xen Project Hypervisor builds on long history of innovative open-source engineering. Enalapril is a dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration). 37% of reviewers reported a positive effect, while 44% reported a negative effect. Maximum daily dose is 40 mg. An overview of the clinical pharmacology of enalapril. Applies to: enalapril and Bactrim (sulfamethoxazole / trimethoprim) Using trimethoprim together with enalapril may increase potassium levels in the blood. It works by decreasing certain chemicals that tighten the blood vessels, so blood flows. R J MacFadyen , P A Meredith H L Elliott. Enalapril 75847-73-3 Suppliers,provide Enalapril 75847-73-3 product and the products related with China (Mainland) Enalapril 75847-73-3 Hunan chemfish Pharmaceutical co. Enalapril is a prescription medicine that is effective at lowering elevated blood pressure and addressing other problems related to constricted arteries and blood vessels. Initiation of sacubitril/valsartan, even when titrated to target dose, did not appear to lead to greater discontinuation or dose down-titration of other key guideline-directed medical therapies, and was associated with fewer discontinuations of MRA. Animal studies have revealed evidence of fetotoxicity. The combination of enalapril and hydrochlorothiazide is used to treat high blood pressure. Maintenance: 10-20 mg once daily, up to 40 mg in severe cases, may be given in 2 divided doses if control is inadequate. This activity. The usual dosage of enalapril for dogs is 0. Please select a region / state! Postcode must be between 2 and 10 characters! Buying Lisinopril online. org 11september , 2014 995 100 mm Hg at screening or 95 mm Hg at random - ization, an estimated glomerular filtration rate Enalapril is an inactive drug that is metabolized to the active metabolite enalaprilat. Talk to your doctor before using enalapril together with ibuprofen. They utilize all the critical binding interactions of the. Compare your own system(s) to this result file with the Phoronix Test Suite by running the command: phoronix-test-suite benchmark 2104159-LARA-CC21ASS53strim. Lynbrook, NY 11563. 5Sections 4. Maksimal plasmakoncentration efter ca. Some people have serious side effects after taking enalapril. enalapril ibuprofen. Enalapril is an angiotensin converting enzyme (ACE) inhibitor. Valsartan (Diovan®) 2. ACE inhibitors are most commonly prescribed by doctors to treat high blood pressure and heart failure. The effect on systolic blood pre. Methods: One hundred and forty-four patients aged 61-80. The drug also effectively treats adults with congestive heart failure. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. XEN Crypto is down 0. It inhibits angiotensin I to angiotensin II conversion via competitive inhibition of the angiotensin-converting enzyme (ACE). 25 mg to 1 mg every 12 to 14 hours. ) se absorbe rápidamente y produce concentraciones séricas máximas de enalapril en un término de una hora. 00000645 a year from then and in 2025, $0. Enalapril lowers blood pressure by reducing the production of a substance called Angiotensin II which causes the blood vessels to narrow. loss in sexual ability, desire, drive, or performance. 25 mg 6 hourly via slow infusion over 5 minutes. 5mg, 5mg, 10mg, and 20mg), oral liquids, and injectable solutions. An overview. With any blood pressure medication. Enalapril maleate is 60% absorbed and 40% bioavailable as enalaprilat. Methods and results: A total of 4723 outpatients with stable HFrEF prescribed enalapril, lisinopril, or ramipril were. As a result, enalapril relaxes the blood vessels. S. Puede producir incluso dificultad para. Which assessment does the nurse perform as a priority before administering the medication? A. Brand name: Innovace. desvanecimiento. Enalapril, administrado na forma de maleato de enalapril, é um pró-fármaco utilizado no tratamento da hipertensão e também em casos de insuficiência cardíaca (IC), sendo que seu mecanismo de ação envolve a inibição da enzima conversora da angiotensina (ECA). Days 4 to 7: 5 mg/day in two divided doses. - 195: Daily level/ EMA 50-level (closing in) - 430: trend-based Fib. x. org 11september , 2014 995 100 mm Hg at screening or 95 mm Hg at random - ization, an estimated glomerular filtration ratePMID: 2163450. 6 Individuals with low-renin hypertensive population were still responsive to enalapril. 1111/j. At the New Year, Lukas left open the door to the shed and mice got to the grain. Enalapril has an average rating of 5. Check with your doctor immediately if any of the following side effects occur: Blurred vision. Consider starting an ACE inhibitor in high-risk patients, even if no HTN or CHF. By 2023, the site said that XEN could be worth $0. diarrhoea or vomiting (see and 4. Enalapril Directions. [ 4] É derivado dos aminoácidos L- alanina e L- prolina. In this article on landmark drugs, Jenny Bryan looks at the discovery of captopril and how it changed cardiovascular treatment. 5-5 mg once or twice daily, increased up to 40 mg/day every 1-2 weeks in 2. Using this medicine while you are pregnant can harm your unborn baby. Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. Enalapril Pregnancy Warnings. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these. 4 timer (enalaprilat). Mar Vista Animal Medical Center 3850 Grand View Blvd. Sign In Sign Up Sign In Sign Up Manage this listMineral resource exploration and mining is an essential part of today's high-tech industry. Introduction. Initial dose: 2. In addition, this article aims to highlight pertinent points regarding quinapril as needed by. El enalapril, se considera un medicamento bien tolerado, aunque produce frecuentemente los siguientes efectos secundarios: Tos y ardor en la garganta: afecta de 5 a 10% de las personas tratadas. 5-10mg. Add the remainder of the Ora-Sweet SF diluent and shake well for an additional 30 seconds. Cellular reprogramming can manipulate the identity of cells to generate the desired cell types 1, 2, 3. About enalapril. Ace-inhibitor conversions for all of the common ace-inhibitors based on the estimated potency. Pregnancy, breastfeeding and fertility. 5 mg. Limit your alcohol intake while taking enalapril because enalapril can further lower your blood pressure and increase the risk of side effects. You can use this model nxlog > Logstash > Elasticsearch. Doses should be titrated upward, as tolerated, over a period of a few days or. Catalog No. The price of XEN Crypto (XEN) is $0. e. It is important to distinguish enalapril-induced cough from cough resulting from acute illness, reactive airway disease, and congestive heart failure. Canine blood pressure disease and heart problems can be treated or moderated by Enalapril for dogs. Fosinopril: HFrEF/HTN: 10 mg daily initially, then titrate to effect (max dose 40 mg daily). The more common side effects that can occur with captopril include: dry cough (should go away after you stop taking captopril) dizziness. Adult: Initially, 5 mg once daily. From snake venom to ACE inhibitor — the discovery and rise of captopril. Inactive ingredients include citric acid, mixed berry flavor, purified water, sodium citrate, methylparaben, propyl paraben, xylitol and sucralose. This is reflected by both hemodynamic (decreased blood pressure) and humoral (increased. . A sample config I'm using is as below:Background: We compared the angiotensin receptor-neprilysin inhibitor LCZ696 with enalapril in patients who had heart failure with a reduced ejection fraction. Vomiting, diarrhea, or other condition causing dehydration, since this may lower blood pressure. Very bad dizziness or passing out. 0Overview. Downsides. I’m the NetBSD developer who put some serious amount of work into the amiga port recently. It was originally developed by the University of Cambridge Computer Laboratory and is now being developed by the Linux Foundation with support from Intel,. Dose should be individualised according to patient profile and blood pressure response. 2 mcg/L) 4 hours after a single. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. tightness in the chest. Llame a su médico si tiene algún problema inusual mientras toma este medicamento. 53. ATI Medication Template - Pharmacology - Enalapril (Vasotec) active learning template: medication angela kim student enalapril (vasotecMEDICATION CLASS GENERIC NAME (COMMON/BRAND NAME) INTERACTION EFFECTS MANAGEMENT RECOMMENDATIONS Potassium Sparing Diuretics Eplerenone (Inspra)3-4 Finerenone (Kerendia)3-4 Spironolactone2023-11-11. How and when to take it. Uses. Background and objectives: Most of the pharmacokinetic (PK) parameters for enalapril and enalaprilat were established following determination of the drug and its metabolite, using angiotensin converting enzyme (ACE) inhibition assays. tb02601. The crude mortality at the end of six months (primary end point) was 26 percent in the enalapril group and 44 percent in the placebo group — a reduction of 40 percent (P = 0. Follow-Up Studies. RESTRICCIONES DE USO DURANTE EL EMBARAZO Y LA LACTANCIA. By blocking the formation of angiotensin II, Aqumeldi helps to lower blood pressure and increases the supply of blood and oxygen to. See full list on drugs. Insufficient evidence is available to definitively say one ACEI is superior to another and should be used preferentially, even with new meta-analyses emerging. The current CoinMarketCap ranking is #2247, with a live market cap of not available. Enalapril is an angiotensin-converting enzyme (ACE) inhibitor that is primarily used in veterinary medicine to treat heart failure and high blood pressure. S. vomiting. Dogs who take enalapril should always have access to fresh water because dehydration can lead to. PetCareRx. 0) from the xen. Bioactivation probably occurs in the liver. The dosage of enalapril for dogs to treat CHF ranges from 0. Data sources include Micromedex (updated 5 Nov 2023), Cerner Multum™. One mother taking a single oral dose of enalapril 5 mg and 2 mothers taking a single dose 10 mg 3 to 45 days postpartum had undetectable enalaprilat milk levels (<0. Amlodipine is a long-lasting calcium channel blocker and Enalapril is an ACE inhibitor. It is OK to take enalapril while breastfeeding, but talk to your doctor or pharmacist first. 2. Mortality was. low blood pressure. Quinapril is a medication utilized to manage hypertension, a significant risk factor for coronary heart disease. com. Drug class: Angiotensin Converting Enzyme Inhibitors. The best offers for Lisinopril. They can also help reduce the risk of fatalities after a heart attack (myocardial infarction). Dizziness, lightheadedness, or weakness may occur as your body adjusts to the medication. I wanted use nxlog, there is a possibility to exclude some events from sending to log server. The product code (s) for this leaflet is: PL 14017/0030. En variant av läkemedlet innehåller förutom enalapril även hydroklortiazid (ett diuretikum, urindrivande medel) som förstärker. 1984;18 Suppl 2 (Suppl 2):215S-229S. This activity outlines the indications, action, and contraindications for enalapril as a valuable agent in managing hypertension and other disorders. Enalapril is an angiotensin-converting enzyme (ACE) inhibitor. Enalapril is a pro-drug; following oral administration, it is. 15. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. 9 min for. are trying to get pregnant, are already pregnant, or you're breastfeeding. ACE inhibitors are sold under many names, such as: benazepril (Lotensin®), captopril (Capoten®), cilazapril (Inhibace®), enalapril. Sep 29. sneezing. The optimized method included the following parameters: Column temperature of 25°C, 10% methanol as the mobile phase, pH of 2. In the pathogenesis of CHF, the proteolytic enzyme renin is released. This lowers blood pressure and increases the supply of blood and oxygen to the heart. Loss of appetite. Forhøjet blodtryk er kun en af flere faktorer, der påvirker denne risiko. 764 mg of enalapril. How and when to take it. Their names were Lukas and Liesl. However, in severe hypertension it may be increased to a maximum of 40 mg once daily. Learn more about using this medicine. Comments: Treatment is usually combined with diuretics and digitalis. $574 retail. Find patient medical information for enalapril-hydrochlorothiazide oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Antihypertensive . 16) and the pooled mean net change in. Checking the client's peripheral pulses C. The usual starting intravenous dose is 1. 8 Department of Pharmacology and Toxicology, Radboud Institute of Health Sciences, Radboudumc, Nijmegen, the Netherlands; Department of Intensive Care and Pediatric Surgery, Erasmus MC - Sophia Children's Hospital, Rotterdam, the Netherlands. Enalapril (Vasotec) doesn't cause many side effects, but some include tiredness, dizziness, and cough. 5 or 5 mg, both given orally BID. Los Angeles, CA 90066 (310)391-6741. Stephen Davis, in xPharm: The Comprehensive Pharmacology Reference, 2007. The following side effects may get better over time as your body gets used to the medication. ENALAPRIL (e NAL a pril) treats high blood pressure and heart failure. The assumption that all drugs in one class are interchangeable is difficult to refute or support, but the lack of evidence on both sides shouldn’t form the basis for drug. Medscape - Hypertension dosing for Vaseretic (enalapril-hydrochlorothiazide), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. These values coincide with maximum inhibition of ACE [12], and over the usual therapeutic range, there is a direct linear correlation between the C max of enalaprilat. Angiotensin-converting-enzyme (ACE) inhibitor is the name used to describe a group of medications used to treat high blood pressure. Echocardiography / veterinary. Reducción de la proteinuria (pérdida de proteínas en la orina). It is sparingly soluble in water,. nausea. Diarrhea. Enalapril Maleate is an uncoated tablet prescribed to help manage the symptoms of heart failure, whether mild, moderate or severe, high blood pressure and some other heart conditions. The boy was handsome as the sun and the girl was beautiful as the moon, but both were lazy and ungovernable. A N T H O N Y/Getty Images. Hypertension is a “life time” condition and, if left untreated, leads to lethal complications. Your doctor may increase your dose as needed. 15. See editorial on page 2974. It lowers peripheral vascular resistance without causing an increase in heart rate. Captopril. XENUSDT: targets based on trend-based Fib (3D-chart) XEN is close to the LoW (Low of the Week). Enalapril User Reviews & Ratings. O. Serious side effects of enalapril include: Fainting. nausea. Get free savings. 1 In recent years. Treatment of dogs with CHF secondary to. One mother taking a single oral dose of enalapril 5 mg and 2 mothers taking a single dose 10 mg 3 to 45 days postpartum had undetectable enalaprilat milk levels (<0. Enalapril. 9% on enalapril. Squibb Institute for Medical Research, Princeton, NJ 08540-0130. com. Enalapril is an angiotensin-converting enzyme (ACE) inhibitor that is commonly prescribed by veterinarians to treat high blood pressure in cats and dogs. If you need this product or more information please feel easy to contact with FINETECH INDUSTRY LIMITED. The usual oral dose for treating high blood pressure is 2. sore throat. 5 mg once a day titrated upward until blood pressure is controlled up to a maximum of 40 mg orally daily in single or 2 divided doses. 1. Los principales son: Reducción de la presión arterial. Enalapril lowers your blood pressure and makes it easier for your heart to pump blood around your body. ACE inhibitors are used for treating high blood pressure and heart failure and. Enalapril is used in the treatment of Hypertension (high blood pressure), Prevention of heart attack and stroke, Heart failure. [4]Depois de sofrer esterificação. The maximum daily dose is 40 mg. These may include vomiting, diarrhea, lack of appetite, weakness, or rashes. 1988 Jun;77 (6 Pt 2):I74-8. 17 Series, Xen Project 4. This lowers blood pressure and increases the supply of blood and oxygen to the heart. 5 mg per day and increase according to response: 10: Start with 2. The aim of this study was to determine the effect of losartan, an antagonist of the angiotensin II type 1 receptor (AT1 receptor), and enalapril, an inhibitor of angiotensin I-converting enzyme (ACE), on viral antigen expression and IL-1β production in peritoneal. 2 out of 10 from a total of 29 ratings on Drugs. Enalapril differs from captopril in several respects. Indeed, a recent metaanalysis concluded that. Background: Placebo-controlled trials have found that angiotensin-converting enzyme inhibitors (ACEIs) decrease proteinuria and slow the progression of nondiabetic nephropathies. Migraine is the most common headache disorder occurring in humans. An angiotensin converting enzyme (ACE) inhibitor, Enalapril 5 MG Tablet helps in the treatment of hypertension, also known as high blood pressure, both in adults as well as children above a month old. Conversion of enalapril to enalaprilat was in the range of 63-76%. It may also be used to prevent further damage after a heart attack. If blood pressure is abnormal, it should then be measured on alternate days until it normalizes. The live XEN Crypto price today is $5. sore throat. 4. Heart Failure. Credit to the U. High Blood Pressure. Drugs. Enalapril, an orally-active, long-acting, nonsulphydryl angiotensin-converting enzyme (ACE) inhibitor, is extensively hydrolysed in vivo to enalaprilat, its bioactive form. The comparative effectiveness of different ACEIs is not known. Enalapril is an angiotensin converting enzyme (ACE) inhibitor. Actúa disminuyendo determinadas sustancias químicas que contraen los vasos sanguíneos, de modo. com. Benazepril. Study design: The Pediatric Heart Network conducted a double-blind trial involving infants with single ventricle physiology randomized to receive enalapril or placebo and followed to 14 months of age. Lisinopril: HTN: Initial 10 mg daily (no diuretic) or 5 mg daily (if on. 53. 546 J Amerena, S Pappas, J-P Ouellet et al. The usual dosage range of enalapril is 10 to 40 mg per day administered in a single or two divided doses; hydrochlorothiazide is effective in doses of 12. In addition, these medications may affect your kidney function, especially when they are used together frequently or chronically. Optimal clinical application of enalapril in the treatment of hypertension and. Compared to enalapril, perindopril significantly improved cardiac sympathetic nerve activity: the pooled mean net change in heart to mediastinum ratio was 0. Cough that does not go away. It has a role as a prodrug, an EC 3. El enalapril, se considera un medicamento bien tolerado, aunque produce frecuentemente los siguientes efectos secundarios: Tos y ardor en la garganta: afecta de 5 a 10% de las personas tratadas. . Hypertensive Emergency. 2. Enalapril is rapidly converted by ester hydrolysis to enalaprilat, a potent ACE inhibitor; enalapril itself. 2165/00003088-199325040-00003. Losartan has an average rating of 4. Swelling of the lips, tongue, throat, face, hands, feet or ankles. If this is intolerable, tell the doctors; falls are very dangerous. • Use cautiously with potassium supplements and potassium sparing diuretics. Side Effects of Enalapril for Cats. The recommended Enalapril dosage for dogs is 0. Enalaprilat is poorly absorbed orally. For glomerulonephritis or protein-losing nephropathy, the dosage can range between 0. Enalapril belongs to a class of medicines called angiotensin-converting enzyme (ACE) inhibitors. Below is a text only representation of the Patient Information Leaflet (ePIL). Combining these medications may reduce the effects of enalapril in lowering blood pressure. REACCIONES ADVERSAS. Enalapril lowers blood pressure in all grades of essential and renovascular hypertension, and peripheral vascular resistance without causing an increase in heart rate. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to. 08 mg/kg (up to 5 mg) once daily. Both drugs can be assayed by high pressure liquid chromatography and by radioimmunoassay and plasma ACE inhibition. com. The overall results of this study . The study was designed to determine the pharmacokinetics, pharmacodynamics, and safety of enalapril ODMTs in the pediatric population with heart failure. Symptoms of high potassium blood level (such as muscle weakness, slow/irregular heartbeat) Signs of infection (such as fever, chills, persistent sore throat) Changes in the amount of urine. Global Rank. Quinapril is an angiotensin converting enzyme (ACE) inhibitor. EPANED is an angiotensin-converting enzyme (ACE) inhibitor indicated for: Treatment of hypertension in adults and children older than 1 month, to lower blood pressure. Pharmacodynamics. 37% of reviewers reported a positive experience, while 44% reported a negative experience. Pregnancy, breastfeeding and fertility. In the Internet there are a lot of examples of nxlog. These targets have confluence with Daily and/or Weekly levels of resistance and/or EMA-levels. FDA approved for use in dogs for heart failure, but is prescribed by. decreased interest in sexual intercourse. 2 out of 10 from a total of 29 ratings on Drugs. Happy anniversary, Xen Project! The best is yet to come and I can’t wait to see what we all. weakness. 1177/106002808602000301. Brand Medications Requiring Use of Generics First You can save money by using safe, effective generic medications when possible. 20-50: Dose as in normal renal function: 10-20: Start with 2. Design: A randomized, double-blind trial. Aqumeldi belongs to a group of medicines called angiotensin converting enzyme (ACE) inhibitors. Angiotensin-converting enzyme (ACE) inhibitors are widely administered to treat chronic congestive heart failure (CHF) in dogs and cats. It is available in brand and generic versions. 7. Agmatine is a chemical found in bacteria, plants, and animals, including humans. Enalapril 10 to 40 mg/day administered either once or twice daily is effective in lowering blood pressure in all grades of essential and. This review aimed to evaluate the benefits of enalapril and losartan in adults with CKD. vomiting. 08 mg/kg (up to 5 mg) once daily. 1 (peptidyl-dipeptidase A) inhibitor, an antihypertensive agent and a geroprotector. Angiotensin-converting enzyme (ACE) inhibitors are widely administered to treat chronic congestive heart failure (CHF) in dogs and cats. Hydrochlorothiazide. Indications and Dosage. Captopril (C 9 H 15 NO 3 S, M w = 217. Diarrhea. Al behandling af forhøjet blodtryk har som mål at mindske risikoen for at udvikle hjerte-kar-sygdom samt tidlig invaliditet eller død. 95, and flow rate of 1. Enalapril is also used to treat a disorder of the ventricles (the lower chambers of the heart that. 40mg/day. Call your doctor for medical advice about side effects. 2) just clone and checkout the proper tag (RELEASE-4. Many ACE inhibitors are available as lower-cost generics. :FT-0625658, Product Name:Enalapril, CAS No. The dosage of enalapril for dogs with hypertension can vary from 0. Enalapril (อีนาลาพริล) คือยาต้านเอนไซม์เอซีอี (Angiotensin Converting Enzyme Inhibitors: ACE Inhibitors) ใช้รักษาความดันโลหิตสูงในผู้ใหญ่และเด็กอายุ 1 ขวบขึ้นไป ภาวะหัวใจล้มเหลวใน. It was created by the Fair Crypto Foundation, backed by Jack Levin – supposedly one of the first Google employees. It contains one molecule of maleic acid for each molecule of enalapril. First of all you will have to get the Xen 4. Enalapril Maleate is the best heart medicine on the market to treat cardiac diseases and blood pressure abnormalities in your pets. Patients taking diuretics: 0. The mean change in SUA from baseline was significantly different at 12 months between 23 hypertensive patients randomised to losartan (3. According to your prescription benefit plan, you will have toThe drugs on this list require step therapy. Find out how enalapril treats high blood pressure (hypertension) and heart failure, and how to take it. The improvement in renal function is postulated to be due to the anti-hypertensive effect, the reduction in mesangial cell proliferation, and renal vasodilation, which causes a decrease in renal filtration pressure and decreased proteinuria. Indications and Dosage. If you have a medical need for one of these drugs, your doctor can ask for an exception. Optimal clinical application of enalapril in the treatment of hypertension and. Enalapril maleate is the maleic acid salt of enalapril. Get emergency medical help if you have signs of an allergic reaction (hives, severe stomach pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). After the first dose, if you do not feel dizzy, you can take enalapril at any time of day. Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in Black patients, and many antihypertensive drugs have additional approved indications and effectsTo evaluate the influence of the angiotensin-converting-enzyme inhibitor enalapril (2. Tesla will only deliver 10 Cybertrucks at its big event this month, executive says. 002). Este efecto surge 1 a 2 semanas luego de haber comenzado el uso de enalapril y puede prolongarse hasta 6 meses. The recommendation for first-line therapy for hypertension remains a beta blocker or diuretic given in a low dosage. 8 and 57. xen-0sd has one repository available.